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This enables the oocytes to pause their expansion and enter a holding pattern, which lasts in the mouse’s adulthood. In mice lacking PRC1, the oocytes didn’t pause their growth; rather, they withered and died in just a month, leaving the mice permanently infertile.
This might help clarify why older Girls are more likely to bear young children with chromosomal Issues like Down Syndrome, during which an additional copy of chromosome 21 finds its way into an oocyte — and later, an embryo.
The grant from the Global Consortium for Reproductive Longevity and Equity (GCRLE) was introduced in June. It's going to give $two hundred,000 in funding, spread about two yrs. With it, Munakata will look at a bit-acknowledged element of reproductive biology: just how an egg mobile stops increasing and enters a Keeping sample, suitable round the time a woman is born.
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